Endocrine Abstracts

Bisphosphonates are powerful inhibitors of bone resorption and have become blockbuster drugs in the treatment of metabolic bone diseases. Enormous progress has been made over the last few years in understanding exactly how bisphosphonate drugs act at the molecular level. After targeting bone and selective internalisation by osteoclasts, nitrogen-containing bisphosphonates potently inhibit FPP synthase. Inhibition of this enzyme disrupts the flux through the mevalonate pathway,...

ObjectiveThere is large inter-individual variation in the growth hormone (GH) response to resistance exercise, but the intra-individual variation is unknown. This study aimed to determine the reproducibility of the GH response to a 30-min resistance exercise session.DesignFollowing local Ethics Committee approval, nine male participants were familiarised before completing three trials in a random order. Durin...